Drug resistance remains a major challenge in the treatment of cancer. The multiplicity\nof the drug resistance determinants raises the question about the optimal strategies to deal with\nthem. Essential oils showed to inhibit the growth of different tumor cell types. Essential oils contain\nseveral chemical classes of compounds whose heterogeneity of active moieties can help prevent the\ndevelopment of drug resistance. In the present paper, we analyzed, by gas chromatography-mass\nspectrometry the chemical composition of the essential oil of the leaves of Kalanchoe beharensis\nobtained by hydrodistillation and compared the chemical composition of its essential oil with that\nof Cyphostemma juttae. Our results demonstrated the anticancer and proapoptotic activities of both\nspecies against acute myeloid leukemia on an in vitro model and its multidrug resistant variant\ninvolving�����.
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